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A platinum pellet injected into Mr. Markov's leg with a spring-loaded umbrella contained a dose of ricin that killed him after three days of intense fever and vomiting.
Our designs can be extended to trials that assume an umbrella ordering of efficacy across doses [ 25], with the same goal of identifying the MaxED.
Although tumor incidence rates may strictly increase with dose, lifetime tumor rates may have an umbrella-shaped or a plateau-shaped dose response curve because of higher mortality in the upper dose groups.
In an umbrella protocol a number of conventional studies (such as SAD, multiple ascending dose (MAD), food effect, drug-drug interaction, ethnic, age and/or gender comparison and cardiac safety studies etc).
We consider multiple types of underlying dose response curves, i.e., monotonically increasing, plateau, or umbrella-shaped.
Your umbrella, where is your umbrella?
I had an umbrella.
Umbrella Moulds Lollies?
Bring the umbrella.
The Umbrella Man.
Keep the umbrella handy.
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