Our ultrastructural data showed that capacitation induces a close apposition of the apical PM with the OAM.
Immunofluorescence data as well as ultrastructural data showed the acquisition by resident fibroblasts of features of myofibroblasts.
Microscopic and ultrastructural (data not shown) examination failed to reveal significant abnormalities in younger animals.
The ultrastructural data provide compelling evidence that this important interneuron subgroup is a direct target of serotonergic innervation.
However, despite showing similar trends to our ultrastructural data, the differences did not reach statistical significance due to relatively large variability between samples (Figure 4B).
Our ultrastructural data not only reveals a defect in early ciliogenesis but also shows that this defect specifically affects the initial elaboration of the distal surface of the basal body and its ability to associate with Golgi derived vesicles.
Finally, the ultrastructural data demonstrated severe effects of MDL28170 in the reservosomes and Golgi, which showed a washed-out appearance with loss of organelles electrondensity and complete disruption of their membranes.
Correlated microscopy approaches will be used to augment ultrastructural data with molecular localization information.
These ultrastructural data are similar to those observed by immunohistochemistry.
These ultrastructural data confirmed the positive regulatory role of QKI-6 and QKI-7 in PNS myelination.
