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N.D.T. oversaw and/or performed histologic and ultrastructural analyses of all tissues.
The ultrastructural analyses of the basilar artery and aorta demonstrated the infiltration of lipid-laden foam cells and the appearance of lipid droplet-filled smooth muscle cells in the monkeys fed with the HFF diet.
A revised interpretation of human corneal nerve architecture is presented based on recent observations obtained by in vivo confocal microscopy (IVCM), immunohistochemistry, and ultrastructural analyses of serial-sectioned human corneas.
However, ultrastructural analyses of canonical glomeruli suggest this is unlikely [26].
Ultrastructural analyses of Drosophila nuclear envelopes lacking Lamin C revealed defects in the nuclear envelope and the nuclear interior.
Ultrastructural analyses of quadriceps muscle showed disorganized sarcomeres and vacuolization of muscle fibers in the knock-in mice as demonstrated in 12-month old mice (Figure 3G I).
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In this report, we used functional assays and ultrastructural analyses to examine ventriculomegaly in four BBS mutant mouse strains widely used as models of ciliopathies.
This was in line with ultrastructural analyses showing aggregation of mitochondria in the cytoplasm of MCK-Cre/cKO muscle fibers (14).
Histological and ultrastructural analyses revealed vasodilation of both peripheral arteries and veins of notch3 mutants, indicating that notch3, which is expressed in the walls of both vessel types, has an essential role in limiting vasodilation.
The future belongs to this sort of combination of methods, i.e., the use of ultrastructural analyses in situ to validate other methods.
Taken together, this study demonstrates that long term formalin fixed and frozen cut brain sections can be used for EM study of ultrastructural analyses, however caution should be taken in interpreting the results of axon density and considerations made for other possible confounds when combining various preparation methods.
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