Sentence examples for ultimately mediate from inspiring English sources

The ERK effector kinases of the Ras/MAPK pathway modify diverse substrates which ultimately mediate cellular pathways controlling cell growth [ 11].

Interactions of FAK with the src family of protein tyrosine kinases (Src-PTKs) have been described as being crucial for the initiation of signalling cascades that ultimately mediate the effects of integrins.

Irrespective of the cause, these signals converge in a group of transcription factors (e.g., nuclear factor-kappa B [NF-κB], activator protein [AP]-1), which induce the synthesis of new molecules that ultimately mediate the inflammatory response to the aggression.

Evidence has been accumulating concerning the role of CTCF in the establishment of intra-chromosomal loops which ultimately mediate protein-protein contacts between distal complexes and the general transcription machinery [ 49, 50].

These TFs cause changes in gene expression that ultimately mediate the phenotypes of a transformed cancerous cell type such as invasion, metastasis, loss of contact-mediated growth inhibition, uncontrolled proliferation, and tumor formation.

The current model of paramyxovirus fusion and pore formation mechanism suggests that upon host cell receptor binding the attachment (H) protein triggers a signal to the fusion (F) protein, which in turn dramatically refolds to ultimately mediate membrane fusion activity [ 16, 17, 33].

Her-2/neu overexpression stimulates the FAS promoter and ultimately mediates increased endogenous fatty synthesis, and this Her-2/neu-mediated induction of breast cancer-associated FAS is inhibitable by trastuzumab.

ICP0 interacts with several cellular and viral proteins, ultimately mediating its effects by regulating gene expression, cell cycle progression and protein expression [16], [17].

Each of these is known to be rewarding for male rodents [32], [33], [34] raising the possibility that the reward value inherent to sexual behavior is what ultimately mediates the beneficial effects of sexual experience on hippocampal neurogenesis.

These social and environmental influences are ultimately mediated through increases in energy intake relative to energy expenditure.

Another possible explanation for such findings arises from the regulatory mechanism of (hemi cellulolytic genes, which is ultimately mediated by environmental conditions, in this case the torrefied substrate.