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The evaluation of mechanism-specific endpoints in EDA is considered to be a promising strategy to facilitate the integration of EDA into weight-of-evidence approaches, ultimately contributing for the identification of environmental contaminants causing bioassay and ecological effects.
In conclusion, endpoint- and mechanism-specific zebrafish bioassays are considered of great relevance not only for guiding EDA studies but also for integrating EDA into environmental assessment and monitoring, ultimately contributing for environmental quality improvement [7,75].
When integrated into broader environmental assessment strategies, EDA guided by specific zebrafish bioassays might support the identification of compounds causing bioassay and ecological effects, ultimately contributing for environmental quality improvement.
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Investments in research for health are mostly made with the aim of ultimately contributing to better action for health.
The high volume of visitors the park and its Manhattan views bring to the neighboring areas has encouraged cultural, commercial, and retail development, ultimately contributing to the rising demand for new residential developments to the downtown Brooklyn area.
Efflux pumps play dual roles, one is to extrude out antibiotics and the other is to assist in biofilm formation through expelling biomolecules important for quorum sensing, ultimately contributing to the virulence of bacterial pathogens.
Rather, delayed timely reinstitution of ventilatory support may allow for deterioration and new organ failure, ultimately contributing to increased mortality and increased costs [ 5].
Thus, cost barriers to dental care act as a catalyst for dental-related time loss from work and school, ultimately contributing productivity losses at a societal level.
Further, cryptic neurodevelopmental deficits evoked by environmental exposures may thus engender a later preference for a high-fat diet to maintain normal ACh function, ultimately contributing to obesity.
Similarly, AGEs can bind to RAGE (receptor for advanced glycated end-products) activating it and triggering several downstream signaling and inflammatory pathways ultimately contributing to oxidative stress.
The results should then constitute evidence for policy formulation and HRH planning and programs, with improved health system performance ultimately contributing to improved population health.
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CEO of Professional Science Editing for Scientists @ prosciediting.com