"The only way that things are going to get fixed is if people get so outraged that they actually start to do something about it.…One thing we know about Washington — it's terribly broken — it is ultimately still amenable to popular action".
These data suggest that DNA methylation of the p16 gene in some breast tumours could be the result of an active process that generates a discrete methylation pattern and, hence, could ultimately be amenable to theraputic manipulation.
Although clinical factors and molecular signatures can partially predict DLBCL outcome, additional information is needed to identify high-risk patients, particularly biologic factors that might ultimately be amenable to intervention.
Although clinical factors such as age, sex, lactate dehydrogenase, extranodal sites, bulky disease, stage, performance status and international prognostic index score can partially predict EFS24, additional factors are needed to identify these high-risk patients, particularly biologic factors that might ultimately be amenable to intervention such as a pathway-targeted therapy.
(Jacobi, 1799: 41) Spinoza knew that truth is its own criterion; that ultimately, therefore, it is not amenable to discursive reason but must be apprehended immediately on its own, intuitively.
But it was widely perceived as a warning to the Palestinians that if they fail to break the negotiating deadlock soon, they may ultimately be confronted with a government far less amenable to compromise on central issues of territory and Jerusalem.
For example, exposure to indoor radon is ultimately determined by local geology and should therefore be amenable to spatial analysis methods, but exposure is so strongly affected by home construction and ventilation (Gunby et al. 1993) as to dilute or eliminate the potential for using region as a marker of individual exposure.
Nonetheless, the facts that HUWE1 is synthetically lethal for MYC-expressing tumor cells and that this is a tractable enzyme amenable to therapeutics raises hope that drugs that target this ubiquitin ligase can ultimately be added to our armament of agents to treat the broad spectrum of aggressive malignancies that have MYC involvement.
The SPRI methodology ultimately allows both column-free cleanup of samples and gel-free size selection, which makes it highly amenable to robust, large-scale multiplexing.
