Sentence examples for ultimately activating from inspiring English sources

As discussed above, the primary receptor for β-glucans is Dectin-1, a CLR that transduces signals via spleen tyrosine kinase (Syk) activation and PKCδ, ultimately activating the NF-κB and mitogen-activated protein kinase (MAPK) pathways [ 60- 62].

In another study, involvement of PKC in TGF-β1-induced cardiac hypertrophic responses by activating TAK1 (another member of the mitogen-activated kinase kinase kinase family) and ultimately activating transcription factor (ATF).

Other possible mechanisms predisposing to headache include local thrombosis, meningeal inflammation, expansion and inflammation of the aneurysm, and bleeding within the vessel wall; ultimately activating nociceptive C-fibers of the trigeminal nerve [4, 15].

These glutamate receptors are coupled with G-proteins and activate phospholipase C, ultimately activating the IP3 receptor (IP3R) to release intracellular calcium, which can alter the function of ECs.

Without rapid restoration of perfusion, these events combine to activate intracellular signalling cascades, ultimately activating the processes of cell death by apoptosis and necrosis, contributing to infarction.

The Toll receptor pathway is a signalling route that responds to the presence of PAMPs by ultimately activating Nf-κB [ 41].

This signalling complex ultimately activates mitogen-activated protein kinases and nuclear factor κB (NFκB), and so stabilizes mRNA and regulates gene transcription [reviewed in Brikos and O'Neill (2008)].

Hh signaling activation ultimately activates downstream Gli transcription factors, which can regulate target gene expression by directly binding to a consensus binding site (5′-TGGGTGGTC-3′) in the target gene promoter [13], [14], [88], [89].

Following are some major pathways identified in our study: - MAPK/Erk signalling: a complex key signalling pathway that is involved in the regulation of normal cell proliferation, survival, growth and differentiation [ 34]; the pathway includes mitogen-activated protein kinases that ultimately activate transcription factors and alter gene transcription.

Indeed, we observed depletion of IAPs and alterations in the levels of apoptosis-related proteins such as Bcl-xL, Mcl-1, Bid and Bim together with the activation of the apoptotic signaling pathway that ultimately activates caspases.

Indeed, the binding of epidermal growth factor (EGF) to its receptor (EGFR) also ultimately activates NF-κB and most likely contributes to the enhanced activity of this transcription factor in ER-negative breast cancer cells [ 16].