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However, they have proved less successful in identifying the ultimate upstream regulators controlling these events, and as such, how drug resistance arises is still unresolved.
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Alternatively, an upstream mechanism that remains unknown may determine birth date and ultimate fate.
Second, upstream and downstream users' initial willingness to participate may determine the ultimate evolutionary stable strategy.
The ultimate go-it-alone indie operator, Carruth wrote, produced, directed, photographed and co-edited Upstream Colour, as well as writing the music and co-starring.
These data suggest that while NF-κB appears to be the ultimate driver of abnormal B-cell activity in MYD88L265P-expressing cells, targeting MYD88 signaling further upstream of NF-κB may be more effective clinically.
This upstream analysis will expedite the development of highly promising translational nanomaterials for in vivo applications and ultimate FDA approval.
31 54 With the ultimate aim of injury control, a successful campaign will encompass a range of strategies to confront the issue upstream (eg, liquor policy and education) and downstream (eg, policing and ample ambulatory resources).
Persisting upstream".
"They come from upstream".
Upstream Gallery, 26B Main Street.
A few steps upstream.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com