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Consequently our study aim was modified, to one investigating features of the local population which might influence the ultimate predictions while preserving the Gail-based modelling approach.
These doomsday ultimate predictions are never correct.
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In the testing process, the outputs by this unified network are discriminated with a threshold value to produce the ultimate prediction for the face verification task.
These observations imply that the most structurally similar drug to Dq in the network is quite important to DDI prediction but it is not the decisive factor for the ultimate prediction in the network system as the AUC for this model is still smaller than that for the model using Set 1.
The following three steps were performed so as to obtain the ultimate prediction model: Determine the "random forest importance" (RFI) by 50 runs of the machine learning algorithm.
For the sake of model stability we adopted an entirely data-driven model building approach which is based on two variable reduction and selection steps (maximizing RFI and minimizing the OOB prediction error by bootstrapping), and a final cross-validated ascending variable introduction strategy, in order to determine the ultimate prediction model [ 21, 22].
Since the degree to which how much drug load hepatocytes "see" intracellularly and the degree drug is metabolized or activated dictate the ultimate prediction of drug-induced toxicity, sandwiched hepatocyte culture represents the current state of the art of in vitro models for hepatotoxicity studies (Swift et al. 2010).
Ultimate strength predictions are made using the von Mises' yield criterion applied to the membrane stresses as collapse criterion.
The accuracy of the method is verified by comparing the ultimate capacity predictions with test results extracted from the literature.
The work presented here concerns the ultimate strength predictions of simply supported, square plates of laminated composite material subjected to uniaxial in-plane compressive load.
The analysis of experimental and numerical continuous beam strengths highlighted that ultimate capacity predictions calculated based on global elastic analysis result in a considerable conservatism due to strain hardening and bending moment redistribution effects.
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