"To think is to add a flame to fire," wrote Balzac, mental activity being in his view an "instrument of destruction that deteriorates our nerves and is the cause of our illnesses and death".Whatever the ultimate cause, heart disease and gangrene got the better of Balzac.
At the ultimate tolerable heart rate during hypothermia, S′ decreased, probably as a consequence of myocardial hypoperfusion due to sustained ventricular contraction throughout a very short diastole.
With the possible exception for the ultimate tolerable heart rate, the slower S′ during hypothermia did not significantly affect systolic emptying, demonstrating that systolic duration was long enough to adequately empty the heart from the actual EDV.
Changes in tau, end-diastolic pressure volume relation, systolic wall thickening velocity, and left ventricular wall dimensions during spontaneous, penultimate, and ultimate tolerable heart rates at normo- (closed symbols) and hypothermia (open symbols).
In experimental animals, diastolic force occurred at supra-physiological frequencies accompanied by reductions in developed force during systole [16] which approximated zero as diastolic force continued to increase towards ultimate tolerable heart rates [27].
Successive shortening of diastolic duration with incomplete relaxation and persisting myocardial contraction throughout diastole as demonstrated by successive increases in EDPVR (Figure 3) could jeopardize myocardial perfusion and thus be responsible for the further slowing of S′ at the penultimate and ultimate tolerable heart rates and the parallel increase in τ.
Doing what's in your heart may possibly be at the ultimate core of what it means to be a rebel.
(Footnote, for any youngsters out there confused by the Christian Slater reference: a long time ago, before he became associated with box-office turkeys and rehab, Slater was the ultimate teen heart-throb. Go watch Heathers and True Romance).
Rick Astley He had a ginger quiff and penchant for wearing trousers so high-waisted that his belt chafed his nipples, but it didn't stop this Lancashire choirboy from becoming the ultimate 80s heart-throb, causing school girls to sob with longing whenever he appeared in his faded denim shirt in the Never Gonna Give.
