Sentence examples for ultimate differentiation from inspiring English sources

Hovav and colleagues described that the priming and boosting vectors influenced the magnitude of the secondary CD8+ T cell response, but that the ultimate differentiation of these cells to memory cells was exclusively shaped by the second immunogen [59].

It has also been reported that TERT overexpression enhances the self-renewal ability of embryonic stem cells, promotes their resistance to apoptosis, and increases their proliferation and ultimate differentiation into hematopoietic lineages [87].

Furthermore, the agent also promoted the ultimate differentiation of human osteoblasts into osteocytes, as indicated by the increased expression of osteocyte-restrictive markers such as dentin matrix protein 1 [ 85].

The latter approach allows to identify alternative scenarios of the cell population splitting into curli-on (biofilm) and curli-off states, while allowing stochastic back- and forth switching or leading to ultimate differentiation, in line with biological observations [ 11].

Functionally-oriented exercises (FOE) were allocated to all study groups specifically with a view to generally enhancing their respective functional capabilities prior to the actual commencement of the other two exercise regimens (SE and PRE) designed as the ultimate differentiation factor.

Taken these evidences together it may envisage that modifications in cell metabolism precede and possibly dictate the nature of the ultimate cellular differentiation.

Our method, involving the use of standard cell culture flasks customised with quartz windows to permit analysis by Raman spectroscopy is simple, easily reproducible and capable of detecting events that accompany the ultimate osteogenic differentiation of DPSCs.

The ultimate markers of differentiation of a functional secreting mammary gland are the milk proteins, which are also direct STAT5 transcriptional targets.

Similarly, we performed dilution cloning of satellite cells to assess the effects of proliferation rate on satellite cells and whereas we observed heterogeneity of proliferation rates amongst satellite cells grown from single cells, we again found no ultimate difference in differentiation efficiency (data not shown).

These signaling molecules play a critical role not only in activating the particular helper T cell but also in determining the ultimate functional role and final differentiation state of that cell.

The limiting factor was to find out an optimal condition for EBECs with ultimate epithelial cell proliferation and differentiation properties.