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Along with the deletion of pseudogenes and superfluous regions, the number of safe spaces for IS insertion will decrease, which in turn will increase the risk for hosting active IS elements and favouring their inactivation and ultimate deletion.
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The term exhaustion has been used to describe the state of functional unresponsiveness, replicative senescence, and ultimate physical deletion of T cells during chronic infection in mice and humans [ 23, 24].
Initiatives similar in concept and ultimate goals to the C. elegans deletion project are underway for several model organisms.
The ultimate goal of this work was to detect genomic deletions potentially associated with disease, so we anticipated that the pertinent alterations might be rare, as has been found for schizophrenia (SZ) [2], [4].
Regardless of the ultimate pathomechanisms, our data further expand the array of deletions in the mitochondrial genomes and its association with liver failure, and as such analysis of mtDNA should be considered in the diagnostic algorithm of childhood-onset hepatopathies.
This model is supported by evidence that elg1 deletion exacerbates mcd1 mutant phenotypes, indicating that Elg1p function is critical for the ultimate maintenance of sister chromatin pairing.
(Deletion is outlawed).
Another day, another deletion.
Ultimate TV.
Ultimate freedom".
Indel insertion and deletion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com