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More difficult was explaining that while Rozalind was doing well there were no guarantees how long the medicines would work or what the ultimate course of her disease might be.
And during the Missouri Compromise debate of 1820, the two men's prescience about the ultimate course of the slavery question -- and their eagerness to die before it comes to pass -- is simultaneously impressive and sad.
Until evidence-based research proves otherwise, it's safe to assume that nonmedical self-help eye exercise programs won't keep you out of glasses if you need them and won't change the ultimate course of your nearsightedness, farsightedness, presbyopia, or astigmatism.
Although studies did not show that medications like donepezil (brand name Aricept) and memantine (Namenda), both used to treat Alzheimer's disease, change the ultimate course of mild cognitive impairment, Dr. Reisberg said they can be useful temporary treatments that may stabilize patients for a few years.
Embedded in its dramatic illustration of the End Times, including a Christian tour of Israel, Waiting for Armageddon offers an object lesson: That if people believe their God has revealed the ultimate course of history, then nothing, not even war, with all its bloodshed and horror, is to be feared.
Nonetheless, consultation with the IRB chair cannot be construed as equivalent to seeking IRB review since the faculty member's ultimate course of action is unknown.
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Which is, of course, of ultimate importance.
Instead he wanted slavery to be "put in course of ultimate extinction".
Early on, Abraham Lincoln talked vaguely about putting slavery on "the course of ultimate extinction".
Now, the ultimate result of that course of action is clear.
Lincoln's election to the White House meant, for South Carolina, that "the public mind must rest in the belief that slavery is in the course of ultimate extinction".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com