Sentence examples for ultimate cell death from inspiring English sources

Such hostile biological effects may range from the commencement of inflammatory pathways through to ultimate cell death [64].

Acetylated p53 can also directly translocate to the mitochondria, inhibiting anti apoptotic proteins BCL-1 and BCL-XL leading to its permeabilization and ultimate cell death [44], [45], [46].

Although these parasites could develop until the midstage of the (subsequent) IDC, the lack of apicoplast functionalities likely causes the ultimate cell death.

The release of Cyt-C may occur secondary to the onset of the mPTP that leads to mitochondrial dysfunction with the loss of ΔΨm and ATP, and the ultimate cell death.

The released cytochrome c forms the apoptosome with Apaf-1 and subsequently activates the initiator caspase, caspase-9, which cleaves and activates effector caspases, caspase-3 and caspase-7, leading to ultimate apoptotic cell death.

Consequently, following the PFM model, the increased caspase activities with the decreased resistance mechanisms of both Akt and Mcl-1 together ensure quick ultimate apoptotic cell death.

Designing drugs to combat neurodegeneration has always looked to cell survival as an ultimate target because cell death is involved both in PD (specifically in the substantia nigra) and in AD (general neuronal loss).

These effector caspases initiate feedback amplification loops and are the ultimate executioners of apoptotic cell death.

It ultimately leads to cell death.

The generation of reactive oxygen species subsequent to reoxygenation inflicts tissue damage and initiates a cellular cascade leading to inflammation, cell death, and ultimate organ failure.

The generation of reactive oxygen species subsequent to reoxygenation inflicts tissue damage and initiates a cascade of deleterious cellular responses leading to inflammation, cell death, and ultimate organ failure.