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The reason for the journey is to find and rescue Meg's father, which requires combat with a satanic figure — an enormous, tentacular black monster that pursues the children throughout the film — and an ultimate agent of evil called only "It".
This external intellect is also the ultimate agent and final cause of the individual intellect.
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Stephen promises to change, but from the moment that he listens lasciviously to Emily's bathwater sluicing down a drainpipe his bad end is already foretold — and the elements of nature, the wind and the water, are the ultimate agents of his doom.
You should be the ultimate agents of change.
Whereas eliminating the ultimate causal agent is not always simple, knowing the immediate mechanism allows for interference with the abnormal, cancer-causing function, in turn facilitating the development of highly effective anticancer drugs.
Philby thus became the ultimate double agent, a British spymaster who was sending everything he knew--which was already a lot and growing more each day--to KGB headquarters in Moscow.
Consequently, the stabilising influence of GSH on 4-OH-CP is removed, leading to increased formation of PM, the ultimate cytotoxic agent.
If toxicity is a direct measure of intracellular concentration, then apparently nickel per se is the ultimate transforming agent independent of source or uptake mechanism.
Nonetheless, an EcR-dependent autocrine signalling that automatically follows EcR activation can be considered part of the hemocyte response to ecdysone signalling, with ecdysone still being the ultimate causal agent for such response.
Unaware of their true nature, they were the ultimate sleeper agents.
By seeking more balance in their lives, their impact on society may well prove women to be the ultimate change agents.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com