For instance, epigenetic mechanisms have been implicated in the programming of cell fate and differentiation [43] [50], in defining ultimate activity levels of specific functional systems [22], [24], and in mediating environmental modulation of genetically-based developmental programs [22], [24], [42], [51], [52].
While modifications to the Fc-domain such as those described above can generally improve therapeutic function, it should be noted that subtle binding properties of the fused partner also make a dominating contribution to the ultimate activity of the biologic in the clinical setting.
It also makes it the ultimate activity holiday destination for graffiti writers". In 2005, he added one of his works to the collection in the British Museum.
There is a complex interplay between calcination temperature, crystal structure, composition and specific surface area, which dictate the ultimate photocatalytic activity in a coordinative manner.
Primarily, IGFBP-6 is tumour suppressive [ 82], but an ultimate link between its activity in vivo remains to be established.
Rhiannon Batten People say to me that fishing must be the ultimate slow activity, but in my experience, what they really want to say is how can I enjoy such a "boring" hobby.
These data suggest that while NF-κB appears to be the ultimate driver of abnormal B-cell activity in MYD88L265P-expressing cells, targeting MYD88 signaling further upstream of NF-κB may be more effective clinically.
The ultimate goal of much of the research activity in dementia is to develop interventions for 'treatment' or even 'cure'cure
However, the present results warrant mechanistic studies to uncover the ultimate mediators of MF's anti-proliferative activity in cancer cells.
The ability to maintain the catalytic activity in dark environment has been the ultimate goal for the widespread deployment of TiO2 photocatalysts.
