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For instance, epigenetic mechanisms have been implicated in the programming of cell fate and differentiation [43] [50], in defining ultimate activity levels of specific functional systems [22], [24], and in mediating environmental modulation of genetically-based developmental programs [22], [24], [42], [51], [52].
However, for compounds with in vivo activity in at least one-third of tested xenograft models, there was correlation with ultimate activity in at least some Phase II trials.
While modifications to the Fc-domain such as those described above can generally improve therapeutic function, it should be noted that subtle binding properties of the fused partner also make a dominating contribution to the ultimate activity of the biologic in the clinical setting.
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Learning to cook, after all, is the ultimate collaborative activity.
"Science is the ultimate global activity," says Richard B. Freeman, a labor economist with the National Bureau of Economic Research.
Rhiannon Batten People say to me that fishing must be the ultimate slow activity, but in my experience, what they really want to say is how can I enjoy such a "boring" hobby.
Language, after all, is the ultimate symbolic activity, and symbolic thought is almost inconceivable without it" (p. 200).
Language is, after all, the ultimate symbolic activity and one that is inextricably entwined with symbolic consciousness as we experience it today.
There is a complex interplay between calcination temperature, crystal structure, composition and specific surface area, which dictate the ultimate photocatalytic activity in a coordinative manner.
Collectively this review highlights the complexity of progestin action and the need for consideration of multiple mechanisms that act in concert to influence their ultimate biological activity.
It can be concluded that, although the C-terminal 173 amino acids are essential for the ultimate enzymatic activity of TorA, they do not influence the formation or stability of the pre-export complex between TorA and TorD.
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