Upper GI complications such as bleeding are more important clinically than ulcers identified at a scheduled endoscopy, although results of endoscopic ulcer trials in NSAID users generally correlate with results in outcome trials assessing upper GI complications (7, 20).
To compare the clinical course of Nocardia species keratitis with keratitis resulting from other bacterial organisms and to assess the effect of corticosteroids as adjunctive therapy using data collected from the Steroids for Corneal Ulcers Trial.
The Steroids for Corneal Ulcers Trial was funded by National Eye Institute grant U10 EY015114.
The Steroids for Corneal Ulcers Trial (SCUT), was a randomized controlled trial investigating the effects of adjunctive corticosteroid therapy to fluoroquinolone (moxifloxacin) treatment on the outcomes of bacterial keratitis [ 25, 26].
The P. aeruginosa isolates used were obtained from the Steroids for Corneal Ulcers Trial (SCUT), a randomized controlled trial investigating the effect of adjunctive corticosteroids on outcomes in bacterial keratitis [ 25].
To determine the relationship between type three secretion genotype and fluoroquinolone resistance for P. aeruginosa strains isolated from microbial keratitis during the Steroids for Corneal Ulcers Trial (SCUT) and for two laboratory strains, PA103 and PAO1.
To determine whether patients who had a positive repeated culture was predictive of worse clinical outcome than those who achieved microbiological cure at 6 days in the Mycotic Ulcer Treatment Trial I (MUTT-I).
Leishmaniasis (184 trials, 23 039 participants) and geohelminth infections; 160 trials, 46 887 participants) were the most studied, while dracunculiasis (nine trials, 798 participants) and Buruli ulcer (five trials, 337 participants) were least studied.
†Primary outcome in these trials was complete healing of all ulcers on trial leg (in the presence of multiple ulcers this would tend to underestimate the outcome of ulcer healing).
The least studied diseases were dracunculiasis (nine trials, total sample size 798) and Buruli ulcer (five trials, total sample size 337).
