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Oral administration of extract showed significant gastric protection effect as the ulcer areas was remarkably decreased.
Ulcer areas on the surfaces of the stomachs were examined macroscopically and measured on square-millimeter paper.
Ulcers were graded using the Wagner classification system and ulcer areas were measured using Visitrak Digital (Smith & Nephew, Hull, England) (20).
Gross ulcer areas, histology, and amount of prostaglandin E2, superoxide dismutase and malondialdehyde were assessed to determine the potentiality of extract in prevention against gastric ulcers.
Ulcer areas and percent granulation were measured by planimetry from manual tracing on a transparent grid sheet, using a validated portable wound measurement device (Visitrack; Smith & Nephew, London, U.K). (18).
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Baseline data included sex, age, primary or recurrent ulceration, ulcer duration, ulcer area, ulcer diameter, appearance of wound bed, ulcer infection, ankle brachial pressure index (ABPI), ankle circumference, ankle mobility, patient mobility, and history of comorbidities such as deep vein thrombosis.
Larger ulcer area at baseline, more chronic ulceration, and previous ulceration were all independent predictors of delayed healing.
Approximately 100 mg of gastric mucosal scrapping from the glandular region (site of ulcer area) near to the ulcerated area was taken into DEPC treated tube and homogenized with 1 ml of denaturing solution.
We re-ran the analysis on a subset of four trials (747 patients, 83/747 dropped) for which additional covariates were available: primary or recurrent ulceration and patients' mobility.w1 w4 w5 w6 The final model contained bandage type, ulcer area, ulcer duration, and primary or recurrent ulceration.
Findings from our meta analysis are consistent with those from prognostic studies in suggesting that baseline ulcer area, ulcer duration, and recurrent ulceration are independent predictors of time to healing.
We found no significant interactions between bandage and baseline ulcer area, bandage and baseline ulcer duration, and bandage and primary or recurrent ulceration.
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