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Thus, impairment of a ubiquitous function of SMN changes the snRNP profile of SMA tissues by unevenly altering the normal proportion of endogenous snRNPs.
The ubiquitous function of DNA repair genes suggested that single promoters might be sufficient to direct transcription without a need for alternative expression patterns.
Despite the general and ubiquitous function of PABPN1, OPMD affects particular muscles and the disease is characterized by eyelid drooping, swallowing difficulties and proximal limb weakness (Brais, 2003).
Given the ubiquitous function of the minor spliceosome in all cell types, the pathological differences between IGDH and MOPD1/TALS, particularly the tissue-specificity, most likely relate to differences in splicing defect severity.
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In vitro, neurons from Loa/Loa embryos exhibited a defect in the fast component of retrograde transport without other alterations in the ubiquitous functions of dynein, such as nuclear motility and Golgi complex morphology and positioning.
One of the most strikingly unexpected findings of our study is that impairment of SMN ubiquitous function specifically alters the snRNP profile of SMA tissues by decreasing the levels of a subset of snRNPs and more prominently of U11.
Insulin signaling is highly conserved across animals, and is known for its ubiquitous function in all aspects of animal physiology.
In fact, the exponential function itself is a very special form, one of an infinite set, of this seemingly ubiquitous function.
Kültz, D. Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous function.
Besides a ubiquitous signaling function of PrPC, we have described a neuronal specificity pointing to a role of PrPC in neuronal homeostasis.
The dichotomy between the ubiquitous housekeeping function of Smn and the very specific neuromuscular SMA phenotype raises the question whether Smn functions differently at the neuromuscular junction (NMJ) than in other tissue types.
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