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Therefore, even high-quality assemblies would typically sequence to no greater than 10x depth of coverage.
Typically, sequence reads of 100bp are taken from both ends of genomic DNA fragments of 200-500bp.
First, GBS approaches typically sequence the flanking regions of restriction enzyme cut sites, which is equivalent to sequencing subsections of the genome taken at random.
Typically, sequence alignment is carried out by formulating and solving an optimization problem - either implicitly or explicitly - where the goal is to maximize an objective function that measures the overall quality of the sequence alignment.
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Scientists have typically sequenced the genomes of organisms that had already been intensively studied.
Tumors are typically sequenced to depths of 75x 100x (exome) or 30x 50x (whole genome).
Handling sequence ends: typically sequences do not start or end with a restriction site.
In children with ASDs, only 21% display genetic differences from the typically sequenced human DNA [ 9].
Typically, sequences have been deposited in a database and all-by-all sequence comparisons with BLAST are conducted to assemble sequence clusters based on similarity.
Our analysis uses partial sequences of the pol gene, comprising approximately 10% of the viral genome, as this is the region typically sequenced for resistance testing.
Deep intronic mutations and mutations outside the typically sequenced regions may account for some of the missing, second mutations in autosomal recessive conditions.
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