Given that GBM is typically localized in one lobe, seldom metastasizes, and exhibits local recurrence, the disease is a proper candidate for local treatments.
The resulting damage is typically localized at the above ground portion of concrete members.
Cardiovascular disease processes such as atherosclerosis, restenosis, and inflammation are typically localized to discrete regions of the vasculature, affording great opportunity for targeted pharmacological treatment.
These cells were typically localized in the center of grafts and were DCX-negative (Fig. 4H).
One class showed irregularly sized foci that were typically localized near each cell pole or randomly positioned within the cell (Figure 3A, Figure S1).
Mature miRNAs hybridize to partially complementary binding sites that are typically localized in the 3' untranslated regions (3'UTR) of target mRNAs [29].
These cells typically localized in areas with few CD8+ T cells in the epithelium or near the border of submucosa (Figure 2).
In contrast, RGS14 is typically localized to the cytosol, nucleus, and perinuclear regions in interphase, and on microtubule structures during mitosis [53] [55].
However, except for instances where distal regions were targeted with viral vectors (e.g., AAV vectors) capable axonal transport, correction of lysosomal storage pathology was typically localized to areas that were proximal to the injection site.
