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The sensitivity of RyR2-G1885E/G1886S to caffeine was significantly reduced, but the channel activation by 5 mM caffeine led to a typical substantial intracellular Ca2+ release in HEK293 cells expressing this doubly mutated RyR2.
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Typical analyses of "substantial equivalence" for transgenic plants stems from the FDA guidelines for inspection, and have traditionally used metabolites, antioxidants, oils, and other molecular compositions as measurements for equivalency [ 15, 16].
A companion article 16 uses datasets and tasks that are typical of a substantial field of immune response evaluation and provides information on the validation of SWIFT's ability to find rare clusters, and also to find clusters that are biologically significant.
The character of the magnetic susceptibility χ(T) curve for the source material is typical for NCM containing a substantial amount of nickel.
However, because the Poisson distribution has the same mean and variance, it often does not reflect typical characteristics such as substantial over-dispersion contained in the count data.
The comparison of these two figures is typical and reveals the substantial difference between the video quality that these two different protocols can deliver.
In particular Ca2+ at typical extracellular concentrations caused substantial aggregation of carboxy-Pdots (40 ± 1.7%) in comparison to hydroxy-Pdots (4.0 ± 0.6%) (P < 0.0001).
When xs ≪ d the acoustic source at the substrate-fluid interface has a substantial gradient, typical of previous SAW digital microfluidics investigations.
In some larger studies, which included patients with a mean age of 60 65 years with a typical age distribution, a substantial proportion of elderly/geriatric patients will be present but not reported separately.
We estimated health costs averted by calculating the reduction in annual probability of transmitting HIV for a person who knows his/her serostatus, has typical risk behavior, has substantial viral load suppression due to partial adherence and with an additional potential decrease of 1 log unit with perfect adherence (Table 1).
The onset of autoimmune hepatitis is usually insidious, as described in western studies with fatigue, fluctuating jaundice and arthralgia as typical features, but a substantial proportion of patients have no obvious signs or symptoms of liver disease or have an acute presentation as seen in 25%% [ 18].
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