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Two types of potency measurements were separately considered, i.e., K i (equilibrium constant) and IC 50 (half-maximal inhibition concentration) values.
Different types of potency measurements should not be combined, e.g., assay-dependent IC 50 measurements and (in theory) assay-independent equilibrium constants (K i values) should be separately considered.
Data sets are separately assembled for different types of potency measurements (i.e., K i and IC 50 values) and provide a resource of scaffolds representing compounds with varying degrees of target promiscuity.
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The types of potency-based possibilities belonging to a species are recognized as possibilities because of their actualization — no natural potency type remains eternally frustrated.
Boethius' view that the types of potencies and potency based possibilities are sometimes actualized is in agreement with the Aristotelian frequency interpretation of modality.
Indeed, unintentional humour in games appears to have a peculiar type of potency today.
To clearly establish the potency difference criterion, it must not only be decided how large a potency difference between two compounds should be but also considered which type of potency measurements should be utilized.
In cases of multiple types of site potency, maps revealing important microstructural behavior and trends are constructed.
The Toxic Equivalence Factor (TEF) is a specific type of relative potency factor (see section 2.2) formed through a scientific consensus procedure [ 10].
By contrast, for the high-confidence set, additional criteria were applied including assay confidence levels as well as the type and integrity of potency measurements.
Potential differences between adverse event profiles may reflect the mechanisms of action, types of targets inhibited, potency, VEGF pathway inhibition selectivity, and pharmacokinetic differences.
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