Our findings link flexible D2-autoreceptor desensitization with Cav1.3 L-type-Ca2+ channel function, through functional expression of NCS-1, and point to a role of this signalling network for adaptive changes in substantia nigra dopamine neuron activity due to altered extracellular dopamine levels.
The comprehensive physical interaction network in yeast is used to show that scale-space based measures consistently give superior performance when distinguishing protein functional categories and three major types of functional interactions genetic interaction, co-expression and perturbation interactions.
Expecting therapeutic effects, we performed two types of functional complementation of HMGB1 by transgenic expression and AAV-mediated expression.
For the fly genome, gene centric databases like Flybase and Flymine (Lyne et al., 2007) provide genomic and protein sequences, annotations, GO terms, protein structure, protein protein interactions and pathway information, as well as various types of functional genomics data, including gene expression profiling and phenotypic information from various screens.
Collectively, the electrophysiology data show that transfection of wild type PKD2 resulted in functional expression in HEK293 cells.
These findings indicate that several types of functional transgenes with either likely altered ECDs or undetectable expression levels can provide sufficient SUB activity.
However it is logical to assume that expression data contains information about various types of functional relations between genes.
Therefore, we investigated whether these intronic DMRs affected different types of functional elements defined by epigenetic marks, which in turn contributed to gene expression changes.
These examples demonstrate that using gene expression profiles as detailed molecular phenotypes can reveal many different types of functional relationships.
She tested five types of functional shoes, leaving her weights at home.
For functional expression of wild type RYE, we expressed it with a human β2 subunit, as insect β subunits typically do not work in heterologous systems (Millar and Lansdell, 2010).
