The objectives of this study were to optimize the number and type of flanking residues that occupy the S3, S2 and S2′, S3′ positions in the PR binding pocket and to select potent lead candidates, which display also favourable ADME-related properties.
For the sdSNPs that were classified according to the type of flanking exons as ASEs or CSEs (Process 2 in Figure 2), filtering out those for which both alleles did not satisfy the GT-AG rule (Process 3 in Figure 2), we subclassified according to the conservation status of flanking exons between human and mouse genomes (Processes 6 and 7 in Figure 2).
They were assessed for the presence of tri- or tetra-nucleotide repeats, repeat number and type, suitability of flanking sequences for primer design and estimated size of product (100 to 350 bp).
Both quantitative (spacing and polarity effects) and qualitative (error types) aspects of flanked letter identification performance, and the cortical localization of the spacing effect, indicate that individuals with PCA commonly develop excessive crowding in central vision.
Wei et al. [12] employed the finite element method to analyze the effects of five types of flank deviation on load distribution of helical gears, and found the superposition property of the influences of individual flank deviation on load distribution.
However, Southern blot also detected two types of segments flanking blaOXA-72 after EcoRI digestion.
To explore homopolymeric tract organisation in functionally-comparable regions of flanking IGR, the median size of type A IGR (promoter) and type C IGR (terminator) of sense-strand flanking sequences upstream and downstream, respectively, of each ORF in 13 Apicomplexan parasite species were obtained (Additional file 1: Table S1).
The phased typing of SNPs flanking the ~11 kb deletion further showed that the three kindreds shared the same haplotype associated with the deletion, which suggests that the deletion in these kindreds arose from a common ancestor.
Sequence comparison of 1.5 2.0 kb of 5' flanking sequence from the 3D7 var genes has defined five upstream types; UpsA, B, C, D, and E types [ 6, 11- 13].
