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DNA-binding specificities of TFs are encoded in their DNA-binding domains that specialize them to recognize and bind specific types of binding sites.
Instead, we prefer to reference recently published crystallographic analyses demonstrating that small molecules may bind multiple proteins in different types of binding sites and with distinct conformations to ultimately facilitate molecular repurposing.
Nowadays the addition of small amounts of chemical additives allows developing new types of binding materials.
Interestingly, two differing types of binding behavior were observed among the three selected anticalins.
Therefore, an MN performs two types of binding update: the global binding update and the local binding update.
Two different parameter sets, 'deeper' and 'surface' were used, for wider coverage of different types of binding sites in proteins.
Finally, a comparison of cell-based binding assays to other types of binding assays will be presented.
According to the molecular structure of gallic acid two types of binding to Tisurf may appear catecholate (OH, OH) or carboxylate (COOH) type.
Studies have shown that these two peaks could be utilized to predict the types of binding interaction between the carboxylate head and metal oxide surface [25].
The presence of two types of binding sites in humic acid, carboxylic and phenolic functional groups, were assumed at both low and high pH conditions.
This is of particular importance for systematic efforts that aim to cover the human proteome with different types of binding reagents.
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