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The first three types of activating mutations disrupt these clasps.
Of the many types of activating covalent modifications observed on p53, phosphorylation has been the most well-studied both biochemically and genetically.
Two types of activating FLT3 mutations, namely FLT3-ITD (an internal tandem duplication mutation in the juxtamembrane domain) and FLT3-KDM (a missense mutation at the Asp835 residue within the kinase domain), account for ∼30% of AML patients (Nakao et al, 1996; Kiyoi et al, 1998; Yamamoto et al, 2001; Gilliland and Griffin, 2002a, 2002b).
The phenomenon of EGFR kinase activation by asymmetric kinase dimerization thus seems to be highly conserved among different members of the EGFR family and different types of activating mutations found in human cancers [ 7, 13].
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Batch and column adsorption experiments were carried out under atmospheric conditions at different levels of CN/Cu using two types of activated carbon.
This paper evaluates the effect of fly ash and slag proportions and the type of activating solution on shrinkage and strength development of alkali-activated binary fly ash-slag mixtures (mortar and paste), cured at room temperature.
A 3k factorial design was used to determine the interaction effects of carbonization temperature, pH, dosage of adsorbent and type of activating agent on the amount of dye removal.
Wang et al have previously shown that the quantity and quality of FRS2 phosphorylation is dependent on the cellular context and type of activating FGFR [ 34].
It is expressed almost ubiquitously in GISTs irrespective of the type of activating mutations, is rarely expressed in other soft tissue tumors, and is positive in KIT-immunonegative GISTs with PDGFRA mutation.
The target genes of the IFN-beta pathway can be divided into three categories according to the type of activating transcription factor: 1) the ISGF3 complex activates genes containing an ISRE binding site in their promoter (e.g. ISG15, Mx1, OAS1, IRF7).
In the last years, our group and others contributed to define the frequency and type of activating oncogenic mutations in MSI and MSS sporadic gastrointestinal tumours, namely occurring in KRAS and BRAF genes, which are members of the MAPKinase pathway (1, 3– 5, 16, 18, 19, 21– 21).
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