In this context, we sought to more accurately define the distribution of a variety of histone modifications within gene bodies across the human genome across several cell types, and relate these patterns to hallmarks of transcriptional activity and chromatin structure.
Centrosome abnormalities, including increased number, size, and microtubule nucleation capacity, are a hallmark of many cancer types, and severity of these defects increases during tumor progression [1].
The coefficient of variation (CoV) across cancer types at the gene, pathway, and hallmark levels.
Neurofibromas are benign tumors of the peripheral nerves and hallmark of neurofibromatosis type 1 (NF1), a tumor suppressor gene syndrome.
Each of these cell types showed the hallmarks of accelerated senescence upon ectopic expression of MEOX2 (Fig. 4, Fig. 5, and unpublished data).
And within those types, they found hallmark genetic changes that are driving many cancers.
In humans, mutations in EDN3 and EDNRB cause Waardenburg-Shah syndrome (Waardenburg syndrome type IV) hallmarked by defects in pigmentation and neonatal bowel obstructions (Amiel et al., 1996; Edery et al., 1996; Hofstra et al., 1996).
Many different cell types comprise the hallmark angioproliferative lesions in KS; however, only the spindle cells, which are of endothelial origin, are infected with KSHV [33] [35].
The ability to differentiate into almost all tissue types as a hallmark of human pluripotent stem cells was analyzed employing embryoid bodies (EBs) based differentiation in-vitro and teratoma formation in-vivo.
Mr. Place is an Australian silversmith who signs his work with a type of hallmark that has been an English tradition since the 15th century.
