Non solid type poorly differentiated adenocarcinoma.
The diffuse subtype included the following Japanese histologic classifications: solid type poorly differentiated adenocarcinoma (por1), non-solid type poorly differentiated adenocarcinoma (por2), signet-ring cell carcinoma (sig), and lymphepithelial-like carcinoma (LE).
The task here is differential diagnosis of three histological types: poorly differentiated, 14; moderately differentiated, 97; well differentiated, 30.
Tubular (moderately differentiated type), poorly differentiated adenocarcinomas, and signet ring cell carcinoma were statistically stable during the period.
It has been reported that diffuse type (poorly differentiated) gastric carcinoma tends to cause intimal thickening of the pulmonary artery [ 9, 11, 24].
Because solid type poorly differentiated colorectal adenocarcinomas are associated with a better prognosis compared to the non-solid type [ 52], we speculate that the intense reactivity with CHO-131 mAb that we observed in highly glandular non-solid type poorly differentiated colorectal adenocarcinomas is an indicator of a poor prognosis.
The histological diagnosis was established according to the World Health Organization International Histological Classification of tumors, with subclassification into two histological categories: differentiated type (well and moderately differentiated tubular adenocarcinoma) and undifferentiated type (poorly differentiated adenocarcinoma and mucinous adenocarcinoma).
Isolated cancer cells of non-solid type poorly differentiated adenocarcinoma (por2) or signet-ring cell carcinoma (sig) are frequently seen in scirrhous gastric cancers with a very poor prognosis.
Further, to check the actual role of MUC4 in non-SRCC type poorly differentiated gastric cancer cells, MUC4 was ectopically overexpressed in a gastric adenocarcinoma cell line (AGS), which has an undetectable expression level of MUC4.
To further analyse the role of MUC4 in the aggressiveness of non-signet ring cell type poorly differentiated gastric adenocarcinomas, MUC4 was ectopically expressed in AGS gastric cancer cell line (using an engineered MUC4 cDNA construct, MUC4minigene (Moniaux et al, 2007)).
