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In this model, all learning experiences will count, and the result may be a new type of transcript that combines all of them, no matter where they take place.
George Siemens, who along with Stephen Downes ran the first MOOC in 2008, recently told the Globe and Mail that he thinks we might be moving toward a "portfolio model of learning". In this model, all learning experiences will count, and the result may be a new type of transcript that combines all of them, no matter where they take place.
All cell lines tested (except CT26 colon carcinoma) expressed at least one type of transcript containing a -2 exon (Figure 5B).
Indeed, these microarrays measure individually the expression of each exon and can therefore not appreciate whether the signal detected is the result of the expression of one unique type of transcript or the mix of different splicing products.
The primers specific to each PLA2 species were designed to confirm whether a given type of transcript was present in the venom gland of a specimen, or whether the corresponding gene was present in the genome of the specimen.
Finally, in the liver and EAE spinal cord, a discrepancy between the results obtained with Ex5-Ex6δ and Ex3b-Ex6δ sets of primers was observed suggesting the presence of at least another type of transcript not detected with these sets of primers.
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Two examples of this type of transcripts are shown in Additional file 3: Figure S3.
Gender, performance status, risk scores, clinical manifestations, blood count, type of transcripts, and presence of additional chromosomal aberrations (ACAs) [ 23] were analyzed at the time of diagnosis.
Splicing alterations in CLL specimens can alter the type of transcripts and thereby function of a large number of cellular proteins that may provide the cell with survival advantage.
It can code for all types of transcript based proteins, is easy and cost efficient to produce, has a favorable safety profile and enables induction of combined immune responses.
Both types of transcript produced essentially the same RNAi phenotypes.
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