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This opens the door to treating each patient in a personalised manner based on the type of mutations they carry and the drugs to which they can be targeted.
This effect is much less pronounced in ProtFP (Feature) as it does not differentiate between the type of mutations (all AAs are encoded as features so every amino acid difference is equal).
Chemical and biological properties of mutagenesis determines the frequencies at which different type of mutations occur, which, in turn, determines their rates of fixation by drift and affects the spectrum of mutations available for selection to operate on.
There was no relationship between the type of mutations and any clinicopathological parameter.
Presence and type of mutations were validated by sequencing in 111 samples.
The type of mutations identified in lasR and rhlR genes are presented in Figure 5 and 6.
Madsen and Browning [27], for example, propose assigning scores to individuals, based on the number an type of mutations present.
The most frequent type of mutations showed abnormal development of the larval sensory organs (14, 37.8% of the total).
Furthermore, whatever the type of mutations, their distribution among any particular analyzed gene in hypermutators and nonmutators isolates did not show any statistically significant differences (Figure 2).
Conversely to the well-known exon skipping, exon exchange has the advantage to be compatible with almost any type of mutations and more generally to a wide range of genetic conditions.
Another study of MDR M. tuberculosis isolates from India [53]only showed an association between rpoB 531 mutations and Beijing genotype, while the type of mutations in the rpoB gene were independent of genotype (spoligopattern) in non-Beijing strains.
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