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Therefore, we suggest that the results of this type of methodological approach should not be considered as valid evidence of progressive resistance to treatment, because they could only mean that patients with more severe forms of the disorder are less responsive to treatment, which occurs with almost all diseases in medicine (Martino et al. 2016).
For each type of methodological problem, they suggested possible adjustments from their experience and from relevant literature.
Table 3 describes, for each type of methodological problem, the proposed adjustments, their feasibility, and costs according to the experts.
The third type of methodological problem is directly linked to the nature of data available to perform this estimation.
Furthermore, no single database specialises in this type of methodological research and it is likely to be found across a wide range of literature.
One of us (YY) presented, domain by domain, each type of methodological problem and proposed adjustments, with detailed examples from the trials in the sample.
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At DIMACS, we are investigating all these types of methodological and modeling issues.
So far we have considered three uniform types of methodological naturalism relating to mathematics: scientific, mathematical, and mathematical-cum-scientific.
Accordingly, there are two fundamental types of methodological inadequacy in current epidemiologic investigations of interaction.
Among the sample of 200 of these trials, 142 were confirmed as high risk; in these, we identified 25 types of methodological problem.
Several types of methodological weaknesses hamper many of the case control studies that have assessed the relative risk of psychoactive substance use for traffic injuries.
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