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Their treatment depends on the specific type of manifestation.
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The treatment is adjusted on the basis of the type of manifestations and their severity and ranges from 'simple' drugs such as colchicine to much more potent immunosuppressive agents such as cyclophosphamide, anti-TNFα agents or alemtuzumab for severe forms.
Another type of manifestations of SNPs is illustrated by the known SNP marker rs10168 (−26G→A) in the human DHFR gene (dihydrofolate reductase; the main target of methotrexate, which is the key drug for the treatment of children with acute lymphoblastic leukemia) [ 81].
An alternative explanation would be that certain types of manifestation were overrepresented in a secondary referral centre like the Charité.
We observed two types of manifestations among the remaining patients.
The underlying factors that lead to these different types of manifestations are not known.
The most common type of skin manifestation, erythema nodosum, presents as raised, tender red nodules usually appearing on the shins.
All patients were submitted to neurological evaluation and classified according to type of clinical manifestation and motor function.
However, no significant differences between HIV-positive and negative subjects were found with regard to type of TB manifestation.
To compare the distributions of ADE severity, causality, type of harm manifestation, and type of events between unrecognized and recognized ADEs, we used the chi-square test or Fisher's exact test.
We hypothesize that an ischemic component reflected by severe Raynaud's phenomenon may be a key trigger for this type of joint manifestation.
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