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(In a logic gate, the two inputs produce one output of a certain value, depending upon the type of gate and the value of the inputs).
Three-quarters of the sculpture's external surface reflects the sky and the name refers to it acting as a type of gate that helps bridge the space between the sky and the viewer.
A further type of gate mechanism, the ball-and-chain inactivation, has not been reported for K2P channels.
In the redox-experiments, Zeng et al postulated that elements of β3b subunits resided sufficiently close to the pore, essentially forming a new type of gate to ion permeation [16].
A more complex type of gate consists of two residues that can rotate but are stabilized in the closed conformation by a mutual interaction.
Because of the extracellular placement of key proton sensing residues, this type of gate has been implicated in the response of a number of K2Ps to external pH (Kim et al, 2000; Rajan et al, 2000; Lopes et al, 2001; Morton et al, 2005; Sandoz et al, 2009).
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A new type of gating has been realized which allows a flexible control of transmission or reflection by the crystal plates.
Cooperative quadratic Boolean input-output systems can use only binary AND, binary OR, and unary COPY gates; the latter type of gates is not allowed in strictly quadratic input-output systems.
This type of gating is widespread among K+ channels, where the glycine hinge is highly conserved [31], in particular in K2P channels, which have hinge glycine residues in their TM2 and TM4 helices [22].
A second type of gating is thought to occur by a sort of constriction of the selectivity filter, first recognized in the form of C-type inactivation [33], and is sensitive to mutations at residues neighboring the external entrance of the pore.
This type of gating is analogous to phenomena often observed with peptide loops in enzymes.
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Justyna Jupowicz-Kozak
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