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Inclusion criteria were: i) age of ≥ 18 years; ii) either epoetin (EPO) pre-treated (any type of EPO) or EPO-naive patients with newly diagnosed renal anaemia; iii) patients had to be exclusively on EPO beta during the course of the study.
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Another type of murine EPO-d model is the EPO-Tagh transgenic mouse, which displayed about the same, low Htc (19.3%) in normoxia as in our model [ 38].
The first of these molecules, desialylated-EPO or asialo-EPO, was first discovered whilst assessing the biological activity of EPO [ 17].
Reports have demonstrated local existence and production of Epo in the tumor mass in several different cancer types such as hepatocellular carcinoma [ 2, 3], renal cell carcinoma [ 4, 5], gastric carcinoma [ 6], thymic carcinoma [ 7], and lung adenocarcinoma [ 8].
As age-matched wild-type and young (6 months) FBM swine without the atherogenic diet showed the same EPO-R expression as young and healthy animals, the reduced EPO-R expression may not only provide a plausible explanation for ineffectiveness of EPO in this model, but also potentially hint at one of the underlying causes of 'EPO resistance'.
Our way of sustained release of EPO by the EPO-PLGA microspheres could help in circumventing the short clearance time of systematic EPO [ 4].
Amgen is selling a new version of EPO called Aranesp.
The blood test can detect the use of EPO over several weeks, but only indirectly.
"We're still going to use the same amount of Epo".
The ongoing "Epo-TBI" study will clarify therapeutic potentials of Epo in patients with TBI (clinialtrials.gov: NCT00987454).
Dephosphorylation of JAK can be induced by phosphatase with the consequent internalization and degradation of the EPO/EPOR complex, which marks the end of EPO activity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com