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The combined results support the hypothesis for a twofold role of K in the mechanism of membrane fusion: 1) to bring opposing membranes into close proximity via coiled-coil formation and 2) to destabilize both membranes thereby promoting fusion.
Our results prove the twofold role of P2X7 in the course of ALS and establish that P2X7 modulation might represent a promising therapeutic strategy by interfering with the neuroinflammatory component of the disease.
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The motivation is twofold: we believe that the role of knowledge requires attention in DRR research, policy, and practice.
The aim of this retrospective study was twofold: (1) to show the role of multi-detector computed tomography angiography (MDCTA) in the evaluation of intracranial arterial anatomic variations; (2) to highlight their clinical importance with illustrated example cases.
The purpose of this investigation was twofold: (1) to examine the role of low- to moderate-intensity, short-duration physical activity on subjective appetite and (2) to identify the role of and associations between ventilation threshold (VeT) and energy intake at a pizza lunch 30 min after glucose and whey protein drinks in normal weight boys.
The aims of this study were twofold: first, to examine the role of self-presentation within the lived-experience of choking in sport; and second, to explore whether the 2 × 2 framework of self-presentation (Howle, Jackson, Conroy, & Dimmock, 2015) holds the potential to further our understanding of acute sporting failure under pressurized conditions.
The significance of these findings is twofold: first, they identify an important role of interstitial flow for in vitro microvascular organization and stabilization, and second, they demonstrate for the first time notable differences between LEC and BEC response to the biophysical environment, reflecting some of their functional differences in vivo.
The role of Supply Division is twofold: to procure essential supplies for health and nutrition, education and recreation, drinking water and sanitation, and to provide technical support in the identification and procurement of emergency supplies as well as in-country logistics.
In the context of dose dense therapy the role of taxanes is twofold, firstly to impart a cytotoxic effect and secondly to improve the feasibility of carboplatin delivery by utilising the platelet sparing effect of paclitaxel [ 13, 14].
We propose that following myocardial infarction and the role of S1P is twofold: mobilization of BMSPCs from their BM niches as well as promoting their subsequent differentiation into myocardial and endothelial lineages thereby further aiding in myocardial repair following ischemic injury.
Therefore, a twofold research question was formulated: 'What is the role of networking in the development and implementation of innovations and what factors influence this relationship?'.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com