Sentence examples for twofold restriction from inspiring English sources
To focus on genes with reliable measurements, the normalized data were filtered for data that had present call in ≥33% of all samples (based on flag information of Agilent Feature Extraction Software v.9.5.3) and the genes chosen by parametric test (don't assume variances equal) with a Bejamini and Hochberg false discovery rate (FDR) <0.01 and twofold restriction filters were utilized.
The reason for imposing the restriction is twofold.
When we examined fetal weight in the context of twofold gene expression, growth restriction of Phlda2+/+BACx1 fetuses was apparent at embryonic day 18.5 (E18.5; 1184.4±8.7 mg versus 1073.8±18.5 mg, P=5.33×10−6) but not at E14.5 or E16.5 (Fig. 1B), similar to the growth profile we reported in response to fourfold expression (Tunster et al., 2010).
This restriction fulfills a twofold purpose.
This finding genetically assigned growth restriction to the twofold-elevated Phlda2 expression.
These data formally assigned the late fetal growth restriction phenotype to twofold-elevated expression of Phlda2 and confirmed that loss of function of Phlda2 does not induce fetal overgrowth.
Patients with the DRD3 MspI G allele (presence of MspI restriction site) had a non-significant twofold higher risk of non-ergoline DA treatment discontinuation (95% CI 0.61 7.17).
Postmenopausal breast cancer risk increases twofold in women who gain significant amounts of weight [ 1] and there is evidence that energy restriction may reduce risk [ 2].
The explanation is twofold.
