Used and loved by millions
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com
twofold increase compared to
Grammar usage guide and real-world examplesUSAGE SUMMARY
The phrase "twofold increase compared to" is correct and usable in written English.
It can be used when discussing a quantitative change or growth in relation to a previous measurement or value. Example: "The company reported a twofold increase compared to last year's sales figures."
✓ Grammatically correct
Science
Alternative expressions(20)
as frequently as
as repeatedly as
as once as
as poorly as
a duplication of
twice the quantity of
as ever as
as well as
double in magnitude compared to
as twofold as
increased by a factor of two
as thoroughly as
as twice as
as before as
as back as
as closely as
as carefully as
as simultaneously as
double the amount of
as often as
Table of contents
Usage summary
Human-verified examples
Expert writing tips
Linguistic context
Ludwig's wrap-up
Alternative expressions
FAQs
Human-verified examples from authoritative sources
Exact Expressions
1 human-written examples
The use of optimal spacer sequences resulted in a 7.7-fold increase in cleavage likelihood compared to epitope pairs without spacer sequences and a twofold increase compared to epitope pairs with a fixed AAY spacer.
Science
Human-verified similar examples from authoritative sources
Similar Expressions
59 human-written examples
Our consideration is based on the evidences that the animals were healthy during and till the end of the experiment (no evidences of discomfort and no loss of body weight or decrease of appetite) and the serum levels of both creatinine and urea were twofold increased compared to the controls but still within acceptable levels.
The value for Ix increased almost twofold from Cx. Value of IONPx also increased compared to Cx (P < 0.05).
As expected from their enhanced PSMA affinities, the DOTAGA ligands 68Ga/177Lu-11 and 68Ga/177Lu-12 showed up to twofold increased internalization compared to the corresponding DOTA ligands 68Ga/177Lu-10.
Science
However, the surface area of pretreated rice straw increased twofold compared to the control.
Science
The levels of both transcripts in the remodeling myocardium of untreated rats increased twofold as compared to sham-operated controls, an increase greatly reduced by spironolactone.
The proportion of students with suicidal ideation in one month was highest in grade 7 when the children entered junior high school (urban area: 19.2%; rural area: 17.1%), which is an increase of twofold to threefold compared to that observed during elementary school years.
Science
The total β cell volume in PDL tail increased twofold as compared to Sham tail.
Science
Traveling to Las Vegas is associated with a twofold increase in risk compared to traveling elsewhere.
Science
Furthermore, investigators at our laboratory have reported that gender differences in heart disease may result from altered collagen deposition, because mesenteric collagen showed a twofold increase in males compared to age-matched females between 4 and 20 weeks of age [ 7, 57].
Science
Finally, labelled sterols recovered from faeces were increased approximately twofold, compared to control animals (Fig 4D).
Science
Expert writing Tips
Best practice
When using "twofold increase compared to", ensure that the quantities being compared are clearly defined to avoid ambiguity. For example, specify units and context precisely.
Common error
A common mistake is failing to clearly establish the baseline value to which the increase is being compared. Always provide context to what is being compared.
Source & Trust
82%
Authority and reliability
4.6/5
Expert rating
Real-world application tested
Linguistic Context
The phrase "twofold increase compared to" functions as a quantitative comparison, indicating that a certain quantity has doubled relative to a baseline value. Ludwig provides numerous examples demonstrating its use in scientific and academic contexts.
Frequent in
Science
100%
Less common in
News & Media
0%
Formal & Business
0%
Wiki
0%
Ludwig's WRAP-UP
In summary, the phrase "twofold increase compared to" is a common and grammatically correct way to express a doubling in quantity or size relative to a baseline. Ludwig highlights its frequent use in scientific and academic contexts. When writing with this phrase, ensure the baseline and units are clearly defined. Alternatives include "double the increase relative to" or "twice the increase compared with", depending on your audience and desired level of formality. The analyzed examples confirm that it is a tool to demonstrate quantitatively a variation.
More alternative expressions(6)
Phrases that express similar concepts, ordered by semantic similarity:
double the increase relative to
Replaces "twofold" with "double" and restructures the comparison slightly.
twice the increase compared with
Uses "twice" instead of "twofold" and "compared with" instead of "compared to".
a doubling in increase as opposed to
Emphasizes the action of doubling and uses "as opposed to" for contrast.
an increase of two times over
Rephrases the increase in terms of multiplication, using "over" for comparison.
a 100% increase relative to
Expresses the twofold increase as a percentage.
increased by a factor of two relative to
Uses the term "factor of two" to represent the doubling.
magnified twofold when juxtaposed with
More formal and literary, suggesting a noticeable magnification effect.
increased to twice the level of
Focuses on the final level after the increase, relative to a reference.
a duplication compared against
More formal; "duplication" emphasizes the doubling and "compared against" is a synonym.
increased by double in contrast to
This alternative emphasizes the amount of the increase by using "double" and the comparison to another element by using "in contrast to".
FAQs
How do I use "twofold increase compared to" in a sentence?
Use "twofold increase compared to" to describe something that has doubled in quantity or size relative to something else. For example: "The experimental group showed a twofold increase in growth rate compared to the control group."
What's the difference between "twofold increase compared to" and "double the increase relative to"?
Both phrases mean essentially the same thing: a quantity has doubled in comparison to another. The choice between them is often a matter of stylistic preference.
Which is correct, "twofold increase compared to" or "twofold increase compared with"?
Both "compared to" and "compared with" are generally acceptable, though "compared to" is more common in American English, while "compared with" is more frequent in British English. The meaning remains the same.
What can I say instead of "twofold increase compared to" when writing for a general audience?
For a broader audience, consider using simpler language like "twice the increase compared with" or "100 percent increase", which might be easier for some readers to grasp immediately.
Editing plus AI, all in one place.
Stop switching between tools. Your AI writing partner for everything—polishing proposals, crafting emails, finding the right tone.
Table of contents
Usage summary
Human-verified examples
Expert writing tips
Linguistic context
Ludwig's wrap-up
Alternative expressions
FAQs
Source & Trust
82%
Authority and reliability
4.6/5
Expert rating
Real-world application tested