The increase in the uptake of statins between 2000 and 2007 made an even greater contribution to the overall mortality fall: twofold greater than the change in population cholesterol (16% vs 6%), and with equitable benefits across all five SES groups.
The reasons for premature stop of growth are twofold: shear stress falls not only because the vessel radius increases, as discussed but also because metabolic autoregulation limits blood flow to the actual need of the tissue.
The main reasons for the crisis are twofold: first, the substantial fall in real terms of government grant-in-aid over the past decade; and, second, the drop in visitor numbers, mainly because of the recent slump in tourism.
Hence, the uncertainty in PD was set to let 95% of the samples fall within twofold of the point estimate.
In acknowledgment of this, a common practice is to empirically denote models exhibiting mean estimates falling within twofold error from observed PK data as acceptable.
The in vitro assay potency results fell within twofold of the potency seen ex vivo in human whole blood, for two reference compounds with reported clinical data, targeting the same pathway.
The worldwide prevalence of people with dementia is estimated to nearly double every 20 years, reaching 40.8 million in 2020 and 90.3 million in 2040. 1 Dementia affects balance, mobility and gait performance, 2 4 and people with dementia have a twofold increased risk of falls compared to non-demented elderly.
Initially, within the first dozen ablations, the average decrease in respiratory frequency was nearly twofold, and it continued to fall steeply until rhythm cessation (range of frequencies: 0.22 0.007 Hz, Figure 3B [inset shows bi-exponential increase in cycle period], n = 5 slices).
2 4 6 In terms of medications, polypharmacy usually increased the risk of falls higher than twofold, 2 4 and the main group of drugs are benzodiazepines, antidepressants, antipsychotics and antiepileptics.
The Beaver Dam 17 and Blue Mountains Eye 18 studies showed that people with VA levels of 6/7.5 or worse and 6/9 or worse, respectively, had a twofold increase in risk of falls.
