To determine the chromosomal locations of the miRNAs, the data (Chromosome number and basebair location) were extracted from Mirbase database, and the locations of the miRNAs which were dysregulated at least twofold in either direction was listed and mapped.
In order to determine whether the dysregulated miRNAs were chromosomally clustered near one another, we mapped the location of the miRNAs dysregulated at least twofold (in either direction) along the human genome using UC Santa Cruz Genome Browser shown in Figure 2a [2a].
According to the crystal structure, the atomic arrangement on the (010) plane of germanium has a fourfold rotational symmetry, the (111) plane has a threefold rotational symmetry, and the (101) plane has two different twofold rotational symmetric directions.
The data that showed <20% expression values and a twofold change in either direction from the gene median value were excluded.
Among 80 annotated genes, which were more than twofold regulated in either direction, we only identified six genes, for which a role in CE formation and/or epidermal barrier function had been demonstrated (Table 1).
The objective of this study was twofold: to investigate the direction and magnitude of the relation of pre-diabetes with risk of future stroke after accounting for other stroke risk factors, and to evaluate whether this relation varies on the basis of the threshold for impaired fasting glucose or inclusion of impaired glucose tolerance criteria in the diagnosis of pre-diabetes.
The risks inherent in so quickly ending the origami campaign, which featured renditions of the paper labels on Stolichnaya bottles, and going in a drastically different direction are, well, twofold.
The stage directions serve the twofold purpose of both unlocking and enhancing the play's gloomy mystery.
The structure possesses a pseudo-twofold axis along the [100] direction which passes through the O atom at (0.3809, 0.0100, 0.7301).
