Its proposed mechanism of action is twofold, by causing V1 receptor-mediated vasoconstriction in some vascular smooth muscle beds [23], AVP can be utilized as a vasopressor similar to CAs.
However, it is important to note that overexpression of MeCP2 by even twofold can cause related severe neurological defects [ 43, 46], indicating that levels of MeCP2 are tightly regulated and that too little as well as too much functional MeCP2 can cause neurodevelopmental disorders.
Increase in glycerol loading from 26 to 36% caused twofold decrease in glycerol conversion was observed, without affecting the GC selectivity of 100%.
Opsonized by normal serum bacteria (O-Salm) caused twofold increase of apoptotic cells above Salm probes and basal level of apoptosis giving the value of less than 10%).
The twofold increased all-cause mortality risk observed in our young-onset population not treated with insulin is also in line with the twofold increased all-cause mortality risk observed in traditional type 2 diabetes populations, i.e., individuals diagnosed in middle-age and beyond (22, 23).
The secretion of chemokine CXCL1 was not effected by 0.1 μM Cd compared to control, whereas 10 μM Cd caused twofold increase of CXCL1 concentration in RAW 264.7 culture supernatants).
The mechanism responsible for initiation of expression of IGFs in the epithelium has not been identified, but it may be through oestrogen, which causes a twofold to threefold increase in the expression of IGF-I mRNA in human breast tissue implanted as xenografts in nu/nu mice [ 14].
For example, the hormone prolactin increases synthesis of milk proteins in tissue by causing a twofold rise in the rate of mRNA synthesis; but it also causes a 17-fold rise in mRNA lifetime, so that in this case the main cause of increased protein synthesis is the prolonged availability of mRNA.
A twofold view of moral causes, the natural and the divine, provided a philosophical axiom for state supervision of conduct in both the secular and the spiritual spheres.
