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Recognition by RNase E depends on a stem-loop in the CRISPR repeat, whereas base substitutions at the cleavage site trigger the appearance of secondary products, consistent with a two-step recognition and cleavage mechanism.
Focusing on Bodhisattva head images, this paper proposes a two-step recognition method for their modeling style: feature extraction utilizing VGGNet1 and clustering with K-means algorithm.
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This functional subdivision of the peptide-MHC ligand suggests that a two-step process for TCR recognition facilitates the efficient scanning of diverse peptide-MHC complexes on the surface of cells and also makes TCRs inherently crossreactive towards different peptides bound by the same MHC.
The fact remains though that current methods are not secure enough, and we need new security technologies -- such as webcam based color/character recognition for two-step verification or encryption methods to protect data from automated systems or "bots". In any case, we as a nation need to change our priorities.
Wu, L.C., Tuot, D.S., Lyons, D.S., Garcia, K.C. & Davis, M.M. Two-step binding mechanism for T cell receptor recognition of peptide MHC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com