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We have demonstrated the savings in time and resources that can be achieved in using seamless two-arm two-stage trials over conducting each phase separately.
UMVCUEs have also been proposed for use more generally in two-stage trials evaluating a single treatment that allow early stopping for futility only.
Table 2 summarises the sample sizes and durations of phase II two-arm two-stage trials which use culture status at 4 or 8 weeks of follow-up as the primary endpoint for both the intermediate and definitive outcomes.
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Novartis will pay for the final-stage trials.
The drug is in mid-stage trials.
These drugs are in early-stage trials.
Numerous mid-stage trials are ongoing.
Froome claimed the race leader's red jersey after finishing second behind Germany's Tony Martin of HTC in the 10th stage, a 47km time-trial.
He dominated the time trial in the 14th stage, winning by more than 90 seconds and jumping into third place.
If the trial proceeded to the 2nd stage (for each subgroup), then 37 patients per BRAF subgroup were to be evaluated for response.
Stefano Garzelli won the 16th stage of the Giro d'Italia, a mountain time trial, ahead of the world champion Cadel Evans.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com