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Benjamin was referring to the second of Virginia's two-stage trial process.
A common approach to the design of phase II clinical trials in oncology is to conduct a two-stage trial so as to control type I and type II error rates.
This two-stage trial will recruit a total of 290 patients.
(2012) do in the context of a single arm two-stage trial with a binary endpoint.
The model then generates stopping rules for a two-stage trial with RR and TTP.
The study was designed as a two-stage trial according to Gehan (1961) assuming a response rate of 15%.
Similar(44)
We will illustrate features of the UMVUE based on two-stage phase II clinical trial design examples and present results of numerical studies on the properties of the UMVUE in comparison to the usual MLE.
Data are reviewed upon completion of patient accrual to the first stage of a two-stage phase II cancer clinical trial and prior to initiating accrual on the second stage.
Estimation of survival distributions of treatment policies in two-stage randomization designs in clinical trials.
A clinical trial using a two-stage phase II design to assess the response rate and safety profile of imatinib at a dose of 400 mg given twice daily in patients with advanced carcinoid tumors was completed.
Simon R. Optimal two-stage designs for phase II clinical trials.
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