Exact(3)
For the differential expression genes between animals infected for 8 hours and 4 days, we identified 7127 genes that were expressed differentially during two time course (Additional file 4 Table S4).
Enzyme levels were inferred from gene expression measurements of bone-marrow derived macrophage cells in two time course experiments, one in which cells were infected with murine cytomegalovirus (mCMV) and one in which cells were treated with IFN γ.
This apparent discrepancy is likely a function of parental diet, because the first two time course experiments were collected from parents that were maintained on yeast paste as a food source, whereas the third set of samples was collected from parents maintained on semi-defined medium, which contains a higher sugar content (Backhaus et al. 1984).
Similar(57)
The second drawback of the earlier GLM analysis seems to be that it cannot represent the association between two lagged-time courses due to delayed response, since delayed response implies lack of linear association between two time courses.
Comparison of gene expressions in these two time courses at all time points results in 7 expression change profiles, which reflect expression changes caused by miR-124 transfection at different time points.
Fig. 1 shows an example of this kind of analysis over two time courses.
Hence, we chose these two time courses in the current study.
Each set of data consists of two time courses: one for the 18N18 substrate and one for the 24N24 substrate.
The gene shown in Fig. 1b has two time courses in which the phase of peak expression is not similar, and the resultant vector has small magnitude.
VEGF-mediated permeability experimentally appears to occur in a biphasic manner both in vitro and in vivo, although these two time courses do not compare.
The gene shown in Fig. 1a has two time courses in which the phase of peak expression is similar between the time courses, and the resultant vector has large magnitude.
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