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The resulting matrix revealed two prominent clusters with opposite behaviours (Figure 3).
This analysis yielded 4 clusters in the brain (Table 3 B ). Two prominent clusters were located in the precentral gyrus, where effects of reversibility were also seen.
The longest observed IGS1-R transcript contains 10 potential binding sites for Nab3 (UCUU) including two prominent clusters, and seven binding sites for Nrd1 (GUAA/G).
Two prominent clusters with strongly scoring dsRNAs clearly emerge: a "cytosolic ribosome cluster" that consists of 79 genes enriched for GO 0022626: Cytosolic Ribosome and a "proteasome complex cluster" that consists of 36 genes enriched for GO 0000502: Proteasome Complex.
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Three prominent clusters of samples/tumors were identified by this analysis.
Five prominent clusters of co-expressed genes were identified from the RNAi data and formed a network graph containing all genes whose expression levels were altered most significantly by either IFNγ or siRNA treatments (see Figure 4a).
Taken together, these results showed that (i) most root genes, including TFs were shared expressed during root development, (ii) shared expressed root genes underwent significant quantitative changes and these differentially expressed genes were grouped into six prominent clusters, and (iii) genes within each cluster encoded proteins involved in important root developmental biological processes.
Among the developmental stages, four prominent clusters of up-regulated genes were evident these were in (1) aquatic and snail stages, (2) adult female worms [with corresponding down-regulation in males], (3) adult female worms [with no down-regulation in males], and (4) adult males.
The two most prominent clusters are component 1 (34.8% of variance), which includes many ARG, Cu, and ampicillin, and component 2 (19.2% of variance) that clusters the rest of the metals and benzyl-penicillin.
The proteins formed three visually prominent clusters annotated in Figure 3 as A-C.
As shown in Table 2, functional analysis of the five most prominent clusters with contrasting gene expression revealed enrichment of integrin linked kinase (ILK) signaling and epithelial adherens junction signaling pathways, glutathione metabolism, and interferon and pro-inflammatory signaling pathways.
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CEO of Professional Science Editing for Scientists @ prosciediting.com