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An epidemiological study was conducted in two outbreak villages to investigate risk factors for developing illness.
The same pattern has been documented for root-boring Lepidoptera, not included in this study, and for Euxoa cutworms in two outbreak years [31].
Goose isolates from the QHL and Tibet outbreaks in 2006 formed a monophyletic group within sub-clade 2.2.2 and were closely related, providing additional evidence that migratory birds were agents of transmission between these two outbreak sites in China.
The first two outbreak isolates were shown to be highly neurovirulent in a transgenic mouse model, and replicated to high titres at 39.5°C in cultured cells[12], suggesting that by July 2001, after approximately 18 months of circulation, the case-to-infection ratio was likely to have approached the 1∶200 estimated for wild-type 1 virus.
Figure 1 shows the time course of the number of IPs for the two outbreak periods considered in the analysis.
The large variation between the two EcO145 genomes suggests a distinctive evolutionary path between the two outbreak strains.
Similar(40)
The two outbreaks are not comparable.
The two outbreaks have exhausted the centers' resources.
Dr. Jones said the two outbreaks indicated that environmental and other factors beyond contamination might be involved.
The report noted two outbreaks last year among people who had handled baby birds.
Less well known are the two outbreaks of plague that immediately preceded and followed that cataclysmic event.
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