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The review focused on two OSC layers: the photoactive layer and the charge transport layer.
So far, at least twenty genes related to the biosynthesis of ginsenosides have been functional identified, including two OSC genes.
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Four OSC genes of American ginseng, cycloartenol synthase (CAS) [ 26], dammarenediol-II synthase (DS) [ 12, 13], β-amyrin synthase 1 (and), and β-amyrin synthase 2 (AS2) [ 11], exist in the 454 cDNA library.
These six OSCs were able to induce apoptosis and reduce colony formation of leukemic cells.
ChIP-Seq 10 million OSCs were fixed with 1% formaldehyde for 10 min followed by quenching with glycine.
In brief, ∼10 million OSCs or 50 ul dissected ovaries were fixed with 1% or 1.8% formaldehyde, respectively.
Our microarray analyses assessed eight OSCs and two control substances, taxol and lovastatin, at a single dose and with triplicate measurements.
Importantly, six OSCs (compounds H, H5, L, N, O and P) did not markedly reduce the proliferative potential of normal myeloid progenitors, providing further evidence of their tumor specificity.
Six OSCs exhibited tumor-specific killing, having no effect on normal bone marrow, and are thus candidates for future toxicity studies.
The maximum-likelihood (ML) phylogenetic tree shown in Figure 2 depicts two major (OSC and SHC) clades separated by a long internal branch.
Each one consisted of ten nonzero calibration standards for OS and eight for OSC, covering the concentration range from 5 1,500 ng/mL for OS and 20 1,500 ng/mL for OSC measured in the identical calibration standards.
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