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Furthermore, in heterogeneous streambed systems, two or three pathways can simultaneously occur and various parts of the IWT occur at distinct positions relative to the IBSA.
Accordingly, using MBS extract might have advantage orver single active componnents in triggering two or three pathways of apoptosis simultaneously leading to vigorous induction of apoptosis.
In addition to the largest component of the network for HF at t = 0.6, which is largely spanned by the interactions with Jun and Fos, there are several small components of isolated interactions between two or three pathways, which are not present in the LF network.
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Mutants defective in one or two pathways were exposed to a cAMP gradient.
Among the "conserved" transcription factors, some seemed to be pathway specific as they were present only in one or two pathways (e.g. CART1, ETF, RUSH-1α, SF1 and SOX9), while others were present in all or most of the pathways and may represent common regulators of conserved transcriptional co-expression among different pathways.
To initiate the Psi-square algorithm, we chose one or more representative vectors from each of 52 pathways and functional systems to be the query (one vector for pathways with relatively uniform phyletic patterns and two or three vectors for pathways with relatively diverse patterns).
Among the 40 components that are enriched with more than one pathway, 14 contained two or three of the following pathways: 'Calcium signaling pathway', 'Cardiac muscle contraction', and 'MAPK signaling pathway'.
Wnts trigger at least two, likely three pathways that employ Wnt receptors of the frizzled seven transmembrane class.
We found that genes affected by Hcy-thiolactone were significantly enriched in thirty molecular pathways, while genes affected by N-Hcy-protein or Hcy were enriched in thirteen or eleven molecular pathways, respectively.
Specifically, the comparative genomic data demonstrate that a complete pterin branch is absent from the Metazoa sampled, consistent with the hypothesis that animals acquire folate using "intact folate salvage" from digested food (Lucock 2000), putatively maintaining the last two or three steps of the biosynthesis pathway to facilitate salvage of folic acid (figs. 1 and 2).
"If we look at it broadly as a public health issue, we will be much more successful than just trying to address one or two specific pathways".
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